Science Reporting

Flavoured liquids of electronic cigarettes may cause endothelial cell dysfunction according to a new study

A new study, published in the Journal of the American College of Cardiology, finds a link between acute exposure to the flavored liquids of electronic cigarettes and the general use of the latter with a dysfunction of endothelial cells, a condition that often precedes certain heart diseases. Endothelial cells are cells that make up the tissue of the inner part of blood vessels as well as the heart.

To reach this conclusion, the researchers analyzed various healthy subjects without important cardiovascular risk factors. These were five healthy non-smokers, five active cigarette smokers, two users of e-cigarettes and cigarettes and two users of e-cigarettes only. The researchers verified the effects of six commercially available e-cigarette liquids, each with different levels of nicotine, on the endothelial cells of individuals.

The researchers found that all flavored liquids had effects, although different in severity, on cell survival. They also observed the presence of pro-inflammatory markers, known to play a role in vascular diseases, as an effect on the use of these liquids. The strongest toxic effect came from a liquid flavored with cinnamon flavor and another with mentholated tobacco flavor.

According to Joseph C Wu, professor at Stanford Cardiovascular Institute and author of the study, the data “suggest that the use of electronic cigarettes can lead to acute endothelial dysfunction, which we have validated by in vitro exposure of both e-liquids and derived serum to patients using electronic cigarettes.”

The study was presented at the 68th Annual Scientific Session of the American College of Cardiology.